Three New Gens Associated With Alzheimer's Diseaseas

Three New Gens Associated With Alzheimer's Diseaseas - Group of scientists, among which there are Spaniards, have been found 3 new genes associated with Alzheimer's disease is a welcome addition to the best-known, the APOE4, as significant risk factors for the most common cause of Alzheimer's.

The discovery, considered one of the most important in the last 15 years, will allow to reduce the proportion of people who develop the disease by 20%, provided that is achieved to reduce the harmful effects of these genes with treatment.

Three New Gens Associated With Alzheimer's Diseaseas

Julie Williams, Professor of Genética Neuropsicológica and his colleagues at the Centre of the Council of medical research in Cardiff on genetics and genomics neuropsychiatric, Wales (United Kingdom), conducted a comprehensive study of Association, reviewing the entire genetic map about 16,000 people in eight countries. The team identified two new genes--called Clusterin and PICALM-, which increase the risk of developing Alzheimer's disease.

A second study of the genome by Philippe Amouyel and colleagues at the Pasteur Institute of Lille, in France, looked at more than 6,000 people with Alzheimer's and nearly 9,000 healthy in France, Belgium, Finland, Italy and Spain. They identified the Clusterin, as well as a third gene called CR1.

The researchers said that the Clusterin could account for 10% of cases of Alzheimer's disease; PICALM, around 9 percent, and the CR1, 4 percent. In comparison, between 20 and 25 percent of the cases are related to the APOE.

According to scientists, it is still difficult to quantify risks associated with each gene disease, since the three are relatively common. In addition, they stressed that also a combination of unknown genetic factors and other external cause Alzheimer's. But I have clear is that identify genes can help researchers to understand the causes of disease and designing drugs to combat it.

For its part, the Spanish Confederation of sick of Alzheimer's and other dementias (Ceafa) has welcomed the news with "optimism", but also "caution".

Jesús Rodrigo, executive director of Ceafa, sample "wide" of people with which you conducted the work enables thinking that it would provide "consistent results" in the medium term. However, he adds, "we must be cautious", because this does not mean to spend time from now until the arrival of the cure of the disease, which affects about 3.5 million people, including patients, families, and caregivers in Spain.




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